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《Chinese Journal of Critical Care Medicine》 2019-09
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Prognostic value of neutrophil CD64 and procalcitonin in patients with traumatic brain injury

Guo Wei-hong;Sun Qiong-qi;Chen Rui-juan;Department of Emergency,Haikou 120 Emergency Center;  
Objective To explore the prognostic value of neutrophil CD64 and procalcitonin (PCT)in patients with traumatic brain injury(TBI).Methods A total of 162 TBI patients admitted to Haikou 120 Emergency Center were divided into survival group(n=128) and death group (n=34) according to the prognosis of 28 days.Glasgow coma score(GCS)was used to divide the patients into mild group(n=106,9≤GCS≤15) and severe group (n=56,3≤GCS≤8).The changes of neutrophil CD64 and PCT on the 1st,3rd and 5th day in each group were compared.The value of neutrophil CD64 and PCT levels in predicting death in patients with TBI was analyzed using ROC curves. Pearson correlation analysis was used to analyze the correlation between neutrophil CD64 and PCT and GCS score in TBI patients.Results Neutrophil CD64(4.15±1.50 vs.2.40±0.85,6.63±2.10 vs. 3.25±0.96,8.14±2.70 vs.3.40±0.92)and PCT(ng/mL:1.40±0.73 vs.0.34±0.26,2.35± 1.28 vs.0.64±0.38,5.42±2.16 vs.0.58±0.34)levels in the death group on the 1st,3rd and 5th day were significantly higher than those in the survival group(P0.05),and neutrophil CD64 and PCT levels in the death group showed a rising trend(P0.05).Neutrophil CD64(3.90±1.42 vs.2.82± 0.94,6.12±1.85 vs.3.60±0.98,7.86±2.64 vs.3.53±0.87)and PCT(ng/mL:1.27±0.65 vs.0.50±0.32,2.04±1.25 vs.0.82±0.45,5.16±1.97 vs.0.73±0.38)levels in the severe group were significantly higher than those in the mild group on the 1st,3rd and 5th day(P0.05), and neutrophil CD64 and PCT levels in the severe group showed an increasing trend(P0.05).ROC curve showed that the AUC(0.924,95%CI 0.860-0.972)which combined neutrophil CD64 and PCT on the third day predicted the death of TBI patients was the largest,and its sensitivity and specificity were 92.8% and 87.2%,respectively.Correlation analysis showed that neutrophil CD64 and PCT were negatively correlated with GCS score in the death group (r=-0.752,-0.817,P 0.01),and neutrophil CD64 was positively correlated with PCT(r=0.684,P0.01).Conclusion Neutrophil CD64 and PCT are correlated with the severity of TBI patients,and the combination of neutrophil CD64 and PCT on the third day is of high value in predicting the prognosis of TBI patients.
【Fund】: 海南省醫藥衛生科研基金項目(17A200293)
【CateGory Index】: R651.15
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