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《Chinese Journal of Critical Care Medicine》 2019-09
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Effect of glucocorticoid on inflammatory cytokines and miRNA-122a in septic shock

Sang Zhen-zhen;Gao Jie;Jia Chun-mei;Li Yong;Department of Emergency,Cangzhou Central Hospital;  
Objective To observe the effect of hydrocortisone on inflammatory cytokines and miRNA-122 a in patients with septic shock.Methods Total of 125 septic shock patients admitted to the emergency intensive care unit(EICU) of Cangzhou central hospital from Dec.2016 to Dec.2018 were divided into two groups:conventional treatment group(65 cases),Hydrocortisone treatment group(60 cases).The conventional treatment group received basic treatment,while the Hydrocortisone treatment group on the basis comprehensive treatment were given intravenous infusion of hydrocortisone(200 mg,every day) for consecutive 7 days.The serum levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),High mobility family protein B-1(HMGB-1) were determined by enzyme-linked immunosorbent(ELISA) before and after 3 and 7 d of treatment.The expression level of serum miRNA-122 a was detected by real-time PCR.The APACHE II score,SOFA score,liver function,vasoactive drug use time,EICU treatment time and 28 d death rate were compared between the two groups.Results Before treatment,there were no significant difference in serum TNF-α,IL-6,HMGB-1 and miRNA-122 a levels between the two groups(P 0.05).After treatment,the above indexes were lower than those before treatment,and all indexes in the hydrocortisone treatment group were lower than those in the conventional treatment group[TNF-α(pg/mL):3 d 146.29±19.34 vs.165.26±16.45,7 d 118.63±20.48 vs.125.83±16.87;IL-6(pg/mL):3 d 150.73±15.36 vs.237.62±18.45,7 d 124.35±16.28 vs.149.94±19.64;HMGB-1(ng/mL):3 d7.78±1.06 vs.11.72±1.25,7 d 2.49±0.50 vs.3.87±0.64;miRNA-122 a:3 d 1.42±0.46 vs.1.95±0.37,7 d 0.86±0.15 vs.1.18±0.29;P0.01].Compared with the conventional treatment group,the liver function improved obviously[ALT(U/L):3 d77(120.3) vs.72.8(112.4),7 d69(28.2) vs.62.5(20.9);AST(U/L):3 d 80.4(118.5) vs.76.7(105.8),7 d 73.6(29.7) vs.65.9(26.7);TBIL(mg/dL):3 d 1.7(3.4) vs.1.6(2.7),7 d 1.5(0.9) vs.1.4(0.8);P 0.01],and EICU treatment time(d:15.4±6.5 vs.10.7±5.3) were significantly shortened,and the differences were statistically significant(P 0.05).However,there was no statistically significant difference in the 28-day mortality between the two groups(P 0.05).Conclusion Hydrogenation can significantly reduce the expression level of serum miRNA-122 a of patients with septic shock and reduce the levels of inflammatory cytokines,thus reducing liver injury and shortening the treatment time of EICU,but it cannot reduce the 28-day mortality of patients with septic shock.
【Fund】: 河北省科技廳醫學科學研究重點計劃項目(182777156);; 滄州市科技局重點研發計劃項目(183302028)
【CateGory Index】: R459.7
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 YIN Jie,YANG Xiaoyan,YU Jia,et al(Institute of Pharmacy and Pharmacology,University of South China,Hengyang,Hunan 421001,China);The miR-122 Expression Vector Construction and the Down-regulation of Bcl-xL,Bcl-2 Gene Expression[J];中南醫學科學雜志;2013-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Sang Zhen-zhen;Gao Jie;Jia Chun-mei;Li Yong;Department of Emergency,Cangzhou Central Hospital;;Effect of glucocorticoid on inflammatory cytokines and miRNA-122a in septic shock[J];中國急救醫學;2019-09
2 Liu Zhi-qiang;Liang Lu;Xue Hua;Yu Zhan-biao;Qu Hai-long;Wang Zi-qi;Peng Guang-jun;Hebei University;;Value of plasma miRNA-122a,miRNA-146a and miRNA-155a expression for the diagnostic and prognostic evaluation of sepsis[J];中國急救醫學;2017-06
3 YU Jia;TANG Zhengwu;YANG Xiaoyan;Institute of Pharmacy and Pharmacology,University of South China;;Effects of miRNA-122 on BEL-7402 /5-FU cell apoptosis induced by 5-fluracil[J];中南醫學科學雜志;2015-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 YIN Jie,YANG Xiao-yan,YU Jia,et al(Institute of Pharmacy and Pharmacology,University of South China,Hengyang,Hunan 421001,China);MiR-122 Increases Sensitivity of BEL-7402/5-FU Cells to 5-fluorouracil via Up-regulation of Wild-type p53 Protein[J];中南醫學科學雜志;2011-06
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