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《Chinese Journal of Critical Care Medicine》 2019-08
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The potential role and significance of longchain non-coding RNA in sepsis induced cardiomyopathy

Zhang Ling;Zhang Hai-dan;Zhao Jing;Xiao Dan-yang;Li Pei-wu;Department of Emergency Medicine,the Second Hospital of Lanzhou University;  
Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.The mortality rate is still high,and the increasing mortality caused by sepsis induced cardiomyopathy(SIC) is a great challenge for emergency and critical care medicine.The "inflammatory waterfalls" are closely related to the "genetic storms" in sepsis.Long chain non-coding RNAs(IncRNAs) have important effects on sepsis and SIC by regulating the inflammatory reactions and immune regulation processes.This article reviews the inflammatory regulation mechanism of IncRNAs in SIC recently.
【Fund】: 蘭州市人才創新創業項目(2016-RC-52)
【CateGory Index】: R459.7;R542.2
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